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Maternal Venezuelan Ancestry and Anesthesia:
Risk, screening, and management of the MT-ND4 variant in 2026
December 12, 2026 | 7:30 AM - 9:00 AM PT
About
Description
Emerging genetic information continues to shape how anesthesiologists assess risk and plan perioperative care. This webinar will explore the MT-ND4 m.11232T>C variant associated with maternal Venezuelan ancestry and its potential implications for patients undergoing anesthesia.
Attendees will examine the spectrum of clinical presentations following sevoflurane exposure in patients carrying the variant, including delayed emergence, metabolic derangements, and neurologic sequelae. The presentation will also address when preoperative screening may be appropriate, clinical and family-history considerations, ethical considerations surrounding genetic screening, and available testing options and their limitations.
Learning Objectives
- Describe the spectrum of clinical presentations after sevoflurane exposure in patients carrying the MT-ND4 m.11232T>C variant, including delayed emergence, metabolic derangements, and neurologic sequelae.
- Explain the rationale for preoperative screening for the MT-ND4 m.11232T>C variant and identify the clinical and family-history features that should prompt it. Understand ethical considerations surrounding ND4 variant screening.
- Formulate an intraoperative and postoperative plan that minimizes risk in patients known or suspected to carry the ND4 variant.
- Select an appropriate genetic test for the MT-ND4 m.11232T>C variant and understand its limitations.
Registration
Registration is complimentary to all attendees. Please register through our form.
Speakers
Dr. Vincent Hsieh
Dr. Ashley Colletti
Dr. Casey Quinlan
Dr. Katherine Gentry
Policies
Technical Failure Policy
I understand that if there is a technical failure at the registrant's home or workplace that prevents access to the live event, a recording of the session will be provided after the session's conclusion. It is the responsibility of the registrant to confirm system requirements and test their computers prior to the start of the event. If a technical failure is the fault of the service provider and the session is not able to be broadcast as planned after two hours, WSSA reserves the right to reschedule the session. If the registrant cannot attend the rescheduled session live, they will be provided with the recording after the session's conclusion.
Recording Acknowledgement
I understand that each virtual session may be recorded, including chat transcripts. Video recorded during the event may be used for promotional purposes, advertising, and other print and online materials at the sole discretion of WSSA. All registered attendees must consent to this if they plan to attend the live sessions.
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